Comparison of Quality of Life Using Chronic Venous Insufficiency Questionnaire (CIVIQ) and Factors Affecting It in Chronic Venous Insufficiency Patients After Endovenous Microwave Ablation with High Ligation + Stripping

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Miradz Hudaya
Universitas Indonesia
Dedy Pratama
Universitas Indonesia
Dhanasari Vidiawati Sanyoto
Universitas Indonesia

The prevalence of Chronic Venous Insufficiency (CVI) continues to increase globally, with approximately 30-40% of the adult population experiencing varicose veins as an early manifestation of venous insufficiency. To date, there are few studies that compare endovenous microwave ablation (EMA) with conventional management of high ligation and stripping (HLS) in terms of quality of life in CVI patients. This study aimed to assess the difference in quality of life of post-operative CVI patients using the CIVIQ-20 questionnaire, by comparing patients who were treated with EMA versus HLS. This prospective cohort study involved 40 CVI patients from RSCM, Hermina Bekasi Hospital, and Hermina Depok Hospital in the May-June 2025 period. Data was collected using questionnaires. Bivariate analysis with Chi-Square test, Fischer's exact test, Independent T-test, and Mann-Whitney U test. Overall, the mean change (?) of CIVIQ score for EMA vs. HLS was 12.82 ± 6.97 vs. 14.33 ± 6.78 (p = 0.334). In patients ? 60 years of age, the ? CIVIQ score for HLS vs. EMA was 16.17 ± 5.67 vs. 10.89 ± 2.67 (p = 0.029). In female patients, the ? CIVIQ score for HLS vs. EMA was 16.63 ± 5.32 vs. 10.23 ± 4.21 (p = 0.006). No significant difference in ? CIVIQ score between HLS and EMA was found in patients < 60 years of age, male, or patients with obesity compared to normoweight. In 60?year-old CVI patients and female CVI patients, management with HLS resulted in a significantly higher CIVIQ-20 ? score than EMA. This showed a better quality of life in both groups of patients when treated with HLS.


Keywords: endovenous microwave ablation, high ligation and stripping, CIVIQ-20, quality of life, chronic venous insufficiency
Biemans, A. A. M., Van Der Velden, S. K., Bruijninckx, C. M. A., Buth, J., & Nijsten, T. (2011). Validation of the chronic venous insufficiency quality of life questionnaire in Dutch patients treated for varicose veins. European Journal of Vascular and Endovascular Surgery, 42(2), 246–253.
Darwis, P., Pratama, D., Muradi, A., Hamzah, A., Rizqhi, F., & Satriadinatha, G. B. (2024). Adaptation of the CiViQ-20 questionnaire as a measurement instrument on quality of life in chronic venous insufficiency patients in Jakarta, Indonesia. Chirurgia (Turin), 37(4), 243–246.
da Silva, M. F. A., Louzada, A. C. S., Teivelis, M. P., Leiderman, D. B. D., Portugal, M. F. C., Stabellini, N., et al. (2022). Varicose vein stripping in 66,577 patients in 11 years in public hospitals in São Paulo. Revista da Associação Médica Brasileira, 68(12), 1657–1662.
Eberhardt, R. T., & Raffetto, J. D. (2014). Chronic venous insufficiency. Circulation, 130(4), 333–346.
Fan, P., Cong, L., Dong, J., Han, Y., & Yang, L. (2022). Comparison of 5-year outcomes and quality of life between endovenous laser (980 nm) and microwave ablation combined with high ligation for varicose veins. Frontiers in Surgery, 9(October), 1–7.
Gloviczki, P., Comerota, A. J., Dalsing, M. C., Eklof, B. G., Gillespie, D. L., Gloviczki, M. L., et al. (2011). The care of patients with varicose veins and associated chronic venous diseases: Clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. Journal of Vascular Surgery, 53(5), 2S–48S.
González Cañas, E., Florit López, S., Vilagut, R. V., Guevara-Noriega, K. A., Santos Espí, M., Rios, J., et al. (2021). A randomized controlled noninferiority trial comparing radiofrequency with stripping and conservative hemodynamic cure for venous insufficiency technique for insufficiency of the great saphenous vein. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 9(1), 101–112.
Launois, R., Mansilha, A., & Jantet, G. (2010). International psychometric validation of the chronic venous disease quality of life questionnaire (CIVIQ-20). European Journal of Vascular and Endovascular Surgery, 40(6), 783–789.
Le Moine, J. G., Fiestas-Navarrete, L., Katumba, K., & Launois, R. (2016). Psychometric validation of the 14 items chronic venous insufficiency quality of life questionnaire (CIVIQ-14): Confirmatory factor analysis. European Journal of Vascular and Endovascular Surgery, 51(2), 268–274.
Mao, J., Zhang, C., Wang, Z., Gan, S., & Li, K. (2012). A retrospective study comparing endovenous laser ablation and microwave ablation for great saphenous varicose veins. European Review for Medical and Pharmacological Sciences, 16(7), 873–877.
Santler, B., & Goerge, T. (2017). Chronic venous insufficiency – A review of pathophysiology, diagnosis, and treatment. JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 15(5), 538–556.
Subwongcharoen, S., & Chitwiset, S. (2014). Chronic venous disease treated with endovenous microwave ablation: Long-term results and quality of life. Journal of the Medical Association of Thailand, 97(Suppl 6), S76–S80.
Yang, L., Wang, X. P., Su, W. J., Zhang, Y., & Wang, Y. (2013). Randomized clinical trial of endovenous microwave ablation combined with high ligation versus conventional surgery for varicose veins. European Journal of Vascular and Endovascular Surgery, 46(4), 473–479.
Yang, X., Li, J., Bai, X., Zhou, L., & Xu, W. (2024). Endovenous microwave ablation versus radiofrequency ablation for the treatment of lower limb varicose veins. Annals of Vascular Surgery, 98, 301–308.
Zhao, N., Guo, H., Zhang, Y., Hu, X., He, J. N., Wang, D., et al. (2024). Comparison of endovenous microwave ablation versus radiofrequency ablation for lower limb varicose veins. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 12(1), 101662.