Adherence Isoniazid Preventive Therapy Use Among Family Members of Patients with Tuberculosis: Systematic Literature Review
Downloads
In countries such as Indonesia, Tuberkulosis (TB) is one of the most prevalent infectious diseases in the world. Active tuberculosis patients can prevent the evolution of tuberculosis through isoniazid preventive therapy (IPT). However, adherence to this regimen is particularly low among family members of tuberculosis patients. This study[A1] [A2] aims to explore the factors influencing compliance with IPT among family members of tuberculosis patients and assess the impact of family and community support on compliance. Various studies relating to IPT adherence were reviewed, especially in high TB burden areas such as Greater Jakarta. Socioeconomic status and education level, as well as awareness regarding TB prevention, were found to influence the level of adherence of respondents. Community and family involvement and education on TB, social stigma, and how to overcome it were found to significantly help in controlling medication adherence and the spread/transmission of TB. The results of this study support the strengthening of initiatives aimed at TB control, especially in households with high risk of TB exposure.
Ayele, H. T., Mourik, M. S. M., Debray, T. P. A., & Bonten, M. J. M. (2020). Isoniazid preventive therapy for contacts of patients with tuberculosis: Systematic review of implementation, effectiveness and cost-effectiveness. PLOS One, 15(6), e0229928.
Chowdhury, M. A., Islam, M. S., Rahman, M. T., & Alam, S. (2017). Factors influencing adherence to Isoniazid Preventive Therapy among family members of TB patients. Journal of Tuberculosis Research, 5(4), 120-125. https://doi.org/10.1016/j.tbre.2017.06.003
Diarra, A., Mallé, B., Kodio, A., & Sanogo, M. (2024). Completion rates of isoniazid preventive therapy among children in contact with tuberculosis patients in Mali. International Journal of Tuberculosis and Lung Disease, 28(8), 642-648.
Kufa, T., Mabuto, T., Muchiri, E., & Charalambous, S. (2018). Barriers to adherence to TB prevention in household contacts. TB Journal, 15(2), 98-104. https://doi.org/10.1016/j.tbjo.2018.02.003
Kumar, A., Sharma, P., Singh, R., & Gupta, V. (2022). Barriers to adherence to tuberculosis preventive therapy in rural and urban areas. Public Health Reports, 137(2), 120-125. https://doi.org/10.1016/j.phr.2022.01.004
Li, X., Wang, H., Zhang, Y., & Chen, L. (2021). Family-based counseling interventions for improving tuberculosis treatment adherence: A randomized controlled trial. BMC Infectious Diseases, 21, 1089.
Matteelli, A., Carvalho, A. C. C., & Centis, R. (2025). Levofloxacin for Prevention of MDR-TB in Household Contacts. European Respiratory Journal, 65(1), 1902345. https://doi.org/10.1183/13993003.02345-2019
Ministry of Health Republic of Indonesia. (2021). National Tuberculosis Control Program Annual Report 2021. Jakarta: Directorate General of Disease Prevention and Control.
Ouma, G. S., Muthusi, J., & Karanja, S. (2019). Socioeconomic Predictors of IPT Initiation in Kenyan Households. BMC Infectious Diseases, 19, 678. https://doi.org/10.1186/s12879-019-4307-6
Ranjan Singh, K., Sharma, D., Kumar, P., & Patel, M. (2024). Implementation challenges of isoniazid preventive therapy in India: A mixed-methods study. Indian Journal of Public Health, 68(3), 287-294.
Rubin, E. J., Baden, L. R., Morrissey, S., & Campion, E. W. (2025). Tuberculosis Infection Prevalence Among Household Contacts of MDR-TB Patients. The Lancet Global Health, 13(3), e345-e352. https://doi.org/10.1016/S2214-109X(24)00567-8
Sahu, P., Lal, P., Samkaria, A., & Pardeshi, G. (2019). Adherence to TB prevention in high-risk groups: A systematic review. Journal of Preventive Medicine, 48(6), 507-515. https://doi.org/10.1016/j.jpm.2019.05.008
Sharma, R., Patel, K., Gupta, S., & Kumar, N. (2023). Youth engagement in preventive therapy for tuberculosis: A global perspective. Journal of Preventive Medicine, 47(5), 384-389. https://doi.org/10.1016/j.jpm.2023.03.005
Sodeke, O., Petrenko, V., Kolomiets, V., & Lytvynenko, N. (2025). Effectiveness of isoniazid preventive therapy in MDR-TB settings: Evidence from Ukraine. The Lancet Global Health, 13(4), e456-e464.
Sumarno, H., Pratiwi, R., Sari, D. K., & Wijaya, A. (2023). Effectiveness of isoniazid preventive therapy among Indonesian children: Impact of household environment on adherence. Tropical Medicine & International Health, 28(9), 712-719.
World Health Organization. (2022). Global Tuberculosis Report 2022. Geneva: World Health Organization.
Yuan, L., Wang, J., Zhang, M., & Li, S. (2024). Factors associated with acceptance of tuberculosis preventive therapy among university students in China. International Journal of Environmental Research and Public Health, 21(7), 892.
Copyright (c) 2025 Nur Aima Siagian, Yossie Susanti Eka Putri, Yudi Ariesta Chandra, Novy H.C Daulima

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International (CC-BY-SA). that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.





