Hubungan Kadar Troponin I Serum Dengan Tingkat Keparahan Pasien ST Elevation Myocardial Infarction di RSUP Prof. Dr. I.G.N.G. Ngoerah Bali
DOI:
https://doi.org/10.58344/locus.v5i2.5388Keywords:
troponin I, STEMI, TIMI flow grade, tingkat keparahan, angiografi koronerAbstract
ST Elevasi Miokard Infark (STEMI) merupakan bentuk sindrom koroner akut yang memiliki risiko mortalitas tinggi. Kadar troponin I serum merupakan salah satu penanda biokimia yang mencermikan derajat kerusakan miokard, sedangkan TIMI flow grade (Thrombolysis in Myocardial Infarction) digunakan untuk menilai tingkat keparahan serta prognosis pasien. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar troponin I serum dengan tingkat keparahan pasien STEMI berdasarkan TIMI flow grade.Penelitian ini merupakan studi observasional analitik dengan pendekatan retrospektif. Data diperoleh dari 34 rekam medis pasien STEMI yang menjalani pemeriksaan troponin I dan angiografi koroner di RSUP Prof. Dr. I.G.N.G. Ngoerah Bali. Analisis data dilakukan menggunakan uji Spearman. Ditemukan hubungan signifikan secara statistik antara kadar troponin I dan TIMI flow grade (r = 0,937; p = 0,020), yang menunjukkan bahwa peningkatan troponin I berhubungan dengan peningkatan risiko klinis berdasarkan TIMI flow grade. Sebagian besar pasien berada pada kategori risiko sedang (skor 1), diikuti oleh skor 2, dan skor 0.Dari hasil analisis dapat disimpulkan bahwa ada hubungan peningkatan troponin I dengan keparahan pasien STEMI di RSUP. Prof. Dr. I.G.N.G. Ngoerah Bali.
References
Alhowaish, T. S., Alhamadh, M. S., Alsulayhim, A., Alotaibi, N., Alrashid, A. A., Alhabeeb, A. Y., Alqirnas, M. Q., Alrushid, E., Alnafisah, M. S., & Anversha, A. A. (2024). Intraluminal thrombus of the extracranial cerebral arteries in acute ischemic stroke: Manifestations, treatment strategies, and outcome. Vascular Health and Risk Management, 20, 1–12. https://doi.org/10.2147/VHRM.S435227
Alkarithi, G., Duval, C., Shi, Y., Macrae, F. L., & Ariëns, R. A. S. (2021). Thrombus structural composition in cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(9), 2370–2383. https://doi.org/10.1161/ATVBAHA.120.315754
Amriani, E. A., & Maricar, F. (2024). Karakteristik infark miokard akut pada usia muda. Jurnal Kesehatan Masyarakat, 8, 2996–3005.
Barangkau, A. S. N. D. Y. (2023). Faktor risiko kejadian infark miokard akut di RSUD Lamaddukelleng. Innovative: Journal of Social Science Research, 3, 3124–3131.
Cardoso, M. R., Silva Junior, D. G. da, Ribeiro, E. A., & Rocha Neto, A. M. da. (2018). Correlation between the complexity of coronary lesions and high-sensitivity troponin levels in patients with acute coronary syndrome. International Journal of Cardiovascular Sciences, 31(3), 218–225. https://doi.org/10.5935/2359-4802.20180014
Gibson, M., & Newsham, P. (2018). Meat: Food and science of the animal kingdom. In Food science and the culinary arts. Elsevier. https://doi.org/10.1016/B978-0-12-811816-0.00012-9
Hammarsten, O., Wernbom, M., Mills, N. L., Mueller, C., Giannitsis, E., Jaffe, A. S., Huber, K., Mair, J., Cullen, L., Möckel, M., Krychtiuk, K., & Thygesen, K. (2022). How is cardiac troponin released from cardiomyocytes? European Heart Journal: Acute Cardiovascular Care, 11(9), 718–720. https://doi.org/10.1093/ehjacc/zuac091
Irdan, & Herman. (2022). Faktor risiko penyakit infark miokard akut di Rumah Sakit Umum Dewi Sartika Kota Kendari. Jurnal Ilmiah Karya Kesehatan, 2(1), 1–7. https://stikesks-kendari.e-journal.id/JIKK/article/view/467
Iriana, D., Nurulita, A., & Rauf, D. (2019). Hubungan kadar troponin I dan high-sensitivity troponin I dengan angiografi koroner pada pasien suspek coronary artery disease. Intisari Sains Medis, 10(2), 420–425. https://doi.org/10.15562/ism.v10i2.373
Kurniawan, P. R., Setiawan, A. A., Limantoro, C., & Ariosta, A. (2021). Differences in troponin I and CK-MB values in acute myocardial infarction patients with ST elevation and without ST elevation. Diponegoro Medical Journal, 10(2), 138–144. https://doi.org/10.14710/dmj.v10i2.29601
Leksana, E., & Purnomo, I. C. (2014). Troponin dan manajemen iskemia miokardium perioperatif. Anestesia dan Critical Care, 32(1), 75–85.
Lowe, J. S., & Anderson, P. G. (2015). Contractile cells. In Stevens & Lowe’s human histology (pp. 71–83). Elsevier. https://doi.org/10.1016/B978-0-7234-3502-0.00005-x
Mair, J., Lindahl, B., Hammarsten, O., Müller, C., Giannitsis, E., Huber, K., Möckel, M., Plebani, M., Thygesen, K., & Jaffe, A. S. (2018). How is cardiac troponin released from injured myocardium? European Heart Journal: Acute Cardiovascular Care, 7(6), 553–560. https://doi.org/10.1177/2048872617748553
Miller, L. M., & Gal, A. (2017). Cardiovascular system and lymphatic vessels. In J. F. B. Zachary (Ed.), Pathologic basis of veterinary disease (6th ed., pp. 561–616.e1). Mosby. https://doi.org/10.1016/B978-0-323-35775-3.00010-2
Nofia, N., et al. (2024). Miokardium akut sebagai penentu kualitas hidup (IMA). Jurnal Abdimas Saintika, 1, 89–98. https://jurnal.syedzasaintika.ac.id/index.php/abdimas/article/view/2568
Nugraha, Y. O., & Trihartanto, M. A. (2021). Non-ST segment elevation myocardial infarction dengan alkoholisme dan kebiasaan merokok berat. Proceeding Book National Symposium and Workshop Continuing Medical Education XIV, 576–586.
Nurmala, S. M., & Kamil, A. R. (2019). Kualitas tidur pada pasien infark miokard akut. Indonesian Journal of Nursing Practices, 2(1), 42–47.
Oktabelia, L., Anggraini, D., & Ashan, H. (2022). Hubungan kadar glukosa darah puasa dengan troponin I pada pasien infark miokard akut. An-Nadaa Jurnal Kesehatan Masyarakat, 9(2), 215. https://doi.org/10.31602/ann.v9i2.9235
Remya, R. S., Indiradevi, K. P., & Babu, K. K. A. (2016). Classification of myocardial infarction using multi resolution wavelet analysis of ECG. Procedia Technology, 24, 949–956. https://doi.org/10.1016/j.protcy.2016.05.195
Sahadeo, P. A., Dym, A. A., Berry, L. B., Bahar, P., Singla, A., Cheta, M., Bhansali, R., LaVine, S., Laser, J., & Richman, M. (2021). Eliminating creatine kinase-MB testing in the emergency department. Cureus, 13(5), e15150. https://doi.org/10.7759/cureus.15150
Vermond, R. A., Van Gelder, I. C., Crijns, H. J., & Rienstra, M. (2015). Does myocardial infarction beget atrial fibrillation and atrial fibrillation beget myocardial infarction? Circulation, 131(21), 1824–1826. https://doi.org/10.1161/CIRCULATIONAHA.115.016595
Wibawa, N. A. K., & Rahadiyan, T. (2023). Akurasi simplified clinical electrocardiogram score sebagai prediktor rehospitalisasi dan mortalitas pasien infark miokard akut. Electronic Journal Scientific of Environmental Health and Disease, 4(1), 31–36. https://doi.org/10.22437/esehad.v4i1.29335
Yaker, Z. S., Lincoff, A. M., Cho, L., Ellis, S. G., Ziada, K. M., Zieminski, J. J., Gulati, R., Gersh, B. J., Holmes, D., & Raphael, C. E. (2024). Coronary spasm and vasomotor dysfunction as a cause of MINOCA. EuroIntervention, 20(2), e123–e134. https://doi.org/10.4244/EIJ-D-23-00448
Zhang, S., Zhang, Q., Lu, Y., Chen, J., Liu, J., Li, Z., & Xie, Z. (2024). Roles of integrin in cardiovascular diseases: From basic research to clinical implications. International Journal of Molecular Sciences, 25(7), 4096. https://doi.org/10.3390/ijms25074096
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Ni Putu Arya Pratiwi, Suhartati Suhartati, Roethmia Yaniari, Ibrahim Njoto, I Kadek Susila Surya Darma
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike 4.0 International (CC-BY-SA). that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
